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A B1

CompanyAcme Laboratories Ltd.
Active Ingredientblue chemistry bottle icon Thiamine Hydrochloride
Variants
  • A B1 Tablet 100'pack 100mg

Dose

Treatment and prophylaxis of mild chronic thiamine deficiency

Adult: 10-25 mg daily in single or divided doses.

Thiamine deficiency

Adult: Up to 300 mg daily.

Wernicke-Korsakoff syndrome

Adult: Initially, 100 mg by slow IV Inj over 10 min, then 50-100 mg/day IM or IV until the patient can take oral thiamine.

Incompatibility: Alkaline or neutral solutions and with oxidizing and reducing agents.

Alternative Brands to A B1

Indication

Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra.

Side Effect

IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse. IM: Tenderness and induration.

Potentially Fatal: Very rarely, fatal anaphylactic shock.

Therapeutic Classes

  • Vitamin-B preparations

Indicaitons

  • Delirium
  • Neuritis of pregnancy
  • Beriberi and Wernick's encephalopathy
  • Thiamine and riboflavin deficiency

Precaution

Parenteral admin. Increased daily requirements in pregnancy and lactation.

Mode of Action

Thiamine, a water soluble vitamin, combines with ATP to form thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism.