|Company||Acme Laboratories Ltd.|
|Active Ingredient||Thiamine Hydrochloride|
Treatment and prophylaxis of mild chronic thiamine deficiency
Adult: 10-25 mg daily in single or divided doses.
Adult: Up to 300 mg daily.
Adult: Initially, 100 mg by slow IV Inj over 10 min, then 50-100 mg/day IM or IV until the patient can take oral thiamine.
Incompatibility: Alkaline or neutral solutions and with oxidizing and reducing agents.
Alternative Brands to A B1
Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra.
IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse. IM: Tenderness and induration.
Potentially Fatal: Very rarely, fatal anaphylactic shock.
- Vitamin-B preparations
- Neuritis of pregnancy
- Beriberi and Wernick's encephalopathy
- Thiamine and riboflavin deficiency
Parenteral admin. Increased daily requirements in pregnancy and lactation.
Mode of Action
Thiamine, a water soluble vitamin, combines with ATP to form thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism.