A Card
| Company | Acme Laboratories Ltd. | |
|---|---|---|
| Active Ingredient |  Isosorbide Mononitrate | |
| Variants |
| |
Dose
Adult: PO 20 mg 2-3 times/day. Usual range: 20-120 mg/day.
As LA form: One capsule once daily.
Alternative Brands to A Card
Indication
Heart failure, Angina pectoris
Contra Indication
Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.
Side Effect
Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence.
Potentially Fatal: Severe hypotension and cardiac failure.
Interaction
Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension.
Potentially Fatal: Significant hypotension may occur when used with phosphodiesterase-5 inhibitors.
Therapeutic Classes
- Nitrates: Coronary vasodilators
Indicaitons
- Heart failure
- IHD
- Ischaemic heart disease
- Angina
Precaution
Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation.
Mode of Action
Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).