|Company||Acme Laboratories Ltd.|
Adult: PO 250-500 mg 4 times/day.
Child: 50-100 mg/kg in divided doses every 6 hr.
Alternative Brands to A Clox
Bacterial infections, Staphylococcal infections resistant to benzylpenicillin, Bacterial Meningitis caused by Staphylococcus, Bacterial Pneumonia caused by Staphylococcus, Lower Respiratory Tract Infection, Urinary Tract Infection caused by Staphylococcus Aureus
Hypersensitivity to penicillins.
Neutropenia, agranulocytosis; GI upsets; rash. Sore mouth or tongue. Black hairy tongue.
Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis; anaphylaxis.
May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time w/ anticoagulants. Increased serum concentrations w/ probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.
- Penicillinase-resistant penicillins
- Bacterial infections
- Lower Respiratory Tract Infections
- Staphylococcal infections resistant to benzylpenicillin
- Bacterial Meningitis caused by Staphylococcus
- Bacterial Pneumonia caused by Staphylococcus
- Urinary Tract Infection caused by Staphylococcus Aureus
Renal impairment; pregnancy and lactation. Porphyria.
Mode of Action
Cloxacillin is resistant to degradation by penicillinases. It is particularly useful against penicillinase-producing staphylococci. Highly active against S aureus, S pyogenes, S viridans and S pneumoniae.