A Clox

Company	Acme Laboratories Ltd.
Active Ingredient	Cloxacillin
Variants	A Clox Powder for suspension 100ml 125mg/1.2ml A Clox Injection 5 Vials 500mg/vial A Clox Injection 5 Vials 250mg/vial A Clox Capsule 100's pack 500mg

Dose

Adult: PO 250-500 mg 4 times/day.

Child: 50-100 mg/kg in divided doses every 6 hr.

Alternative Brands to A Clox

Indication

Bacterial infections, Staphylococcal infections resistant to benzylpenicillin, Bacterial Meningitis caused by Staphylococcus, Bacterial Pneumonia caused by Staphylococcus, Lower Respiratory Tract Infection, Urinary Tract Infection caused by Staphylococcus Aureus

Contra Indication

Hypersensitivity to penicillins.

Side Effect

Neutropenia, agranulocytosis; GI upsets; rash. Sore mouth or tongue. Black hairy tongue.

Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis; anaphylaxis.

Interaction

May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time w/ anticoagulants. Increased serum concentrations w/ probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.

Therapeutic Classes

Penicillinase-resistant penicillins

Indicaitons

Bacterial infections
Lower Respiratory Tract Infections
Staphylococcal infections resistant to benzylpenicillin
Bacterial Meningitis caused by Staphylococcus
Bacterial Pneumonia caused by Staphylococcus
Urinary Tract Infection caused by Staphylococcus Aureus

Precaution

Renal impairment; pregnancy and lactation. Porphyria.

Mode of Action

Cloxacillin is resistant to degradation by penicillinases. It is particularly useful against penicillinase-producing staphylococci. Highly active against S aureus, S pyogenes, S viridans and S pneumoniae.