A Fenac K
| Company | Acme Laboratories Ltd. | |
|---|---|---|
| Active Ingredient |  Diclofenac Potassium | |
| Variants |
| |
Dose
Adults: 1- 3 tablet (50 -150 mg) daily in divided doses preferably with food or after food.
Children: 1- 3 mg/kg body weight per day in divided doses. Migraine As K: Initial: 50 mg taken at 1st sign of attack, repeat 2 hr later if needed and subsequently 4-6 hrly if needed. Max: 200 mg/day.
Alternative Brands to A Fenac K
Indication
Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Pain, Migraine, Allergic conjunctivitis, Dysmenorrhea, Muscle aches, Acute gout, Inflammation, Renal colic, Miosis, Tendinitis, Actinic keratosis, Backaches, Dental pain, Menstrual cramps, Bursitis
Contra Indication
It is contra-indicated for those patients who are hypersensitive to Diclofenac. In patients with active or suspected peptic ulcer or gastrointestinal bleeding, or for those patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other NSAIDs possessing prostaglandin synthetase inhibitinig activity, it is also contraindicated.
Side Effect
Side-effects of Diclofenac is usually mild and transient. It is generally well tolerated. At the starting of the treatment, however, patients may sometimes complain of gastrointestinal discomfort, epigastria pain, eructation, nausea and Diarrhoea, headache and bleeding sometime may occur. Occasionally skin rash, peripheral oedema and abnormalities of serum transaminase have been reported.Very rarely reported side effects include activation of peptic ulcer, haematemesis or melena, blood dyscrasia (extensive usage). There have been isolated reports of anaphylactoid reactions.
Interaction
May increase serum levels of methotrexate. Concomitant use w/ other NSAIDs or anticoagulants (e.g. warfarin) is associated w/ higher risk of GI bleeding. Increased risk of nephrotoxicity w/ ciclosporin or triamterene. May increase the risk of developing corneal complications in patients w/ significant pre-existing corneal inflammation when use concomitantly w/ ophth preparation containing corticosteroids. Colestyramine and colestipol reduce the bioavailability of diclofenac. Decreased plasma concentration when administered after sucralfate. Ophth application of diclofenac may reduce the efficacy of ophth acetylcholine and carbachol. May increase serum levels of lithium and digoxin.
Therapeutic Classes
- Drugs used for Rheumatoid Arthritis
- Drugs for Osteoarthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Indicaitons
- Osteoarthritis / degenerative arthritis
- Ankylosing spondylitis
- Musculoskeletal and joint pain
- Pain
- Dysmenorrhoea
- Conjunctivitis
- Migraine
- Allergic conjunctivitis
- Arthritis
- Backache
- Muscle aches
- Back pain
- Low back pain
- Spondylitis
- SLE
- Acute gout
- Muscle spasm
- Inflammation
- Renal colic
- Miosis
- Actinic keratosis
- Dental pain
- Menstrual cramps
- Musculoskeletal pain
- Bodyache
- Pain and inflammation
- Tendonitis
- Bursitis
- Rheumatoid Arthritis (RA)
- Relieve pain
Precaution
History of GI ulceration; impaired cardiac, renal or hepatic function; hypertension; lactation. IV admin in patients with moderate or severe renal impairment; hypovolaemia or dehydration; asthma, porphyria. Monitor LFTs in patients on prolonged therapy. May prolong bleeding time; caution when used in patients with coagulation disorders or on anticoagulants. Prolonged therapy may increase risk of anaemia. 1st and 2nd trimester of pregnancy. Elderly, debilitated patients.
Mode of Action
Diclofenac, a phenylacetic acid derivative is a prototypical NSAID. It has potent anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits the enzyme, cyclooxygenase, thus resulting in reduced synthesis of prostaglandin precursors.