A Flox
| Company | Acme Laboratories Ltd. | |
|---|---|---|
| Active Ingredient |  Flucloxacillin | |
| Variants |
| |
Dose
Adults (including elderly patients):
Oral:
250-500mg three to four times a day. Oral doses should be administered 1 hour before meal
Children
2-10 years: Half of adult dose
Under 2 years: One fourth of adult dose
Children have been given doses of 12.5-25 mg/kg body weight four times a day.
IV 0.25-1 g 4 times/day, may double in severe cases. Up to 8 g/day in 3-4 divided doses may be given for osteomyelitis. Up to 8 g/day in 4 divided doses for endocarditis in patients weighing <85 kg and 12 g/day in 6 divided doses for patients weighing >85 kg.
Renal impairment:
CrCl (ml/min)
<10 Dosage adjustment may be necessary.
Alternative Brands to A Flox
- Fluclox
- Fluclox DS
- A Flox
- Oxacol
- Flumark
- Alfux
- Capflu
- Capflu DS
- Flusyrup
- Staflu
- Staflu DS
- Fluxin
- Monaclox DS
- Monaclox F
- Flutec
- Luf
- Luff
- Sofa
- Stafoxin
- Clox F
- Clox-F
- Fluc
- Belox
- Beloxs
- Flubex
- Flubex DS
- Flubex cap
- Revistar
- Flac
- Flacsp
- Isoflu
- Doribac
- Surgeflox
- Surgeflox ES
- Flucil
- Flonex-500
- Flucloxi
- Auxil
- Flupen
- E Flu
- Eflu
- Flucloxin
- Flucloxin DS
- Fcx
- Floxapen
- Isoclox
- G-Flucloxacillin
- G-flucloxacillin
- Flox
- Skilox
- Floxason
- Sinaflox
- Inclox
- Inclox DS
- Indoflox
- F Clox
- Eflucin
- Flu K
- Flu-K
- Faxilin
- Flutam
- Actinase
- Flumed
- Flucillin
- Flucin
- Flucin DS
- Enoclox
- Flora
- Flubiotic
- Fucil
- Halopen
- Flux
- Flux DS
- Orgaflu
- Flustaph
- Stapkil
- Staphylox
- Flukin
- Flukin DS
- Flubac
- Flubac DS
- Floxirak
- Perpen
- Flustar
- Softapen
- Penflu
- S Fluclox
- S-Fluclox
- Ancoc
- Ancoc PFS
- Silox
- Siloxs
- Flucopen
- Cloxafu
- Phylopen
- Phylopen DS
- Phylopen FORTE
- Fulcin
- Syflu
- Dolopen
- Dolopen DS
- Flxzen
- Fluxi
- Fluxicap
Indication
Pneumonia, Burns, Meningitis, Endocarditis, Sinusitis, Septicaemia, Tonsillitis, Surgical Prophylaxis, Staphylococcal skin infections, Boils, Osteomyelitis, Enteritis,Wounds, Abscesses, Infected eczema, Infected acne
Contra Indication
Hypersensitivity to penicillins. Porphyria.
Side Effect
Hypersensitivity reactions including urticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis; hepatitis, cholestatic jaundice; agranulocytosis; phlebitis (IV infusion).
Potentially Fatal: Anaphylaxis. Stevens-Johnson syndrome
Interaction
May increase the risk of methotrexate toxicity. May decrease the efficacy of oestrogen-containing OC. Enhanced plasma concentrations w/ probenecid. Bacteriostatic drugs (e.g. chloramphenicol, tetracycline) may interfere w/ the bactericidal effect of flucloxacillin. May prolong bleeding time in patients on oral anticoagulants.
Therapeutic Classes
- Penicillinase-resistant penicillins
Indicaitons
- Pneumonia
- Burns
- Meningitis
- Endocarditis
- Sinusitis
- Septicaemia
- Tonsillitis
- Soft tissue infections
- Surgical Prophylaxis
- Staphylococcal skin infections
- Boils
- Osteomyelitis
- Enteritis
- Wounds
- Abscesses
- Infected eczema
- Infected acne
- Complicated skin and skin structure infections
- Uncomplicated skin infections
- Diabetic ulcers
Precaution
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route; elderly. Hepatic impairment.
Mode of Action
Flucloxacillin inhibits the 3rd and last step of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. It is active against penicillinase-producing and non-penicillinase-producing staphylococci.