A Phenicol
| Company | Acme Laboratories Ltd. | |
|---|---|---|
| Active Ingredient |  Chloramphenicol 0.5% Eye drops | |
| Variants |
| |
Dose
Ocular infections
Adult: Instill 1 drop of a 0.5% solution every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing. Reduce dose once symptoms are controlled or apply a 1% ointment 3-4 times daily.
Renal impairment: Dose reduction may be required.
Hepatic impairment: Dose reduction may be required.
Alternative Brands to A Phenicol
Indication
Bacterial Conjunctivitis
Contra Indication
History of hypersensitivity or toxic reaction to the drug; Herpes simplex and other virul conditions of the eye or ear, mycosis.
Side Effect
Ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema.
Interaction
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.
Therapeutic Classes
- Ophthalmic Anti-bacterial products
Indicaitons
- Conjunctivitis
- Bacterial Conjunctivitis
- Bacterial eye infections
- Acute & chronic conjunctivitis
- Occular infection
Precaution
Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.
Mode of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.