A Rox

Company	Ambee Pharmaceuticals Ltd.
Active Ingredient	Roxithromycin
Variants	A Rox Powder for Suspension 50ml bot 50mg/5ml A Rox Tablet 30's pack 150mg A Rox Tablet 20's pack 300mg

Dose

Adult: PO 150 mg twice daily or 300 mg once daily for 5-10 days.

Paediatric dose: The dose for children is 2.5 to 5 mg/kg body weight twice a day.

Alternative Brands to A Rox

Indication

Pneumonia, Pharyngitis, Susceptible infections, Sinusitis, Otitis media, Cellulitis,Tonsillitis, Folliculitis, Carbuncles, Prostatitis, Urethritis, Acute and chronic bronchitis, Bronchopneumonia, Furuncles, Pyoderma, Impetigo and infected dermatitis, Cervicitis and salpingitis

Contra Indication

Hypersensitivity. Porphyria.

Side Effect

Nausea, vomiting, abdominal pain, diarrhoea, weakness, malaise, anorexia, constipation, dyspepsia, flatulence; hepatitis; rashes, headache, dizziness, weakness, changes in blood counts; increased liver enzyme values; eosinophilia; rarely, acute pancreatitis.

Interaction

May raise serum levels of ciclosporin and digoxin. Increased risk of rhabdomyolysis when used with simvastatin.

Therapeutic Classes

Macrolides

Indicaitons

Pneumonia
Pharyngitis
Susceptible infections
Sinusitis
Otitis media
Cellulitis
Bronchitis
Tonsillitis
Folliculitis
Carbuncles
Prostatitis
Urethritis
Bronchopneumonia
Furuncles
Pyoderma
Impetigo and infected dermatitis
Cervicitis and salpingitis
Rhinitis

Precaution

Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias.

Mode of Action

Roxithromycin inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.