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A-Cof

CompanyAcme Laboratories Ltd.
Active Ingredientblue chemistry bottle icon Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride
Variants
  • A-Cof Syrup 100ml bot

Dose

Adult 2 teaspoonful three times a day.

Children

Over 12 years 2 teaspoonful three times a day

6-12 years 1 teaspoonful three times a day

2-6 years 1/2 teaspoonful three times a day or

as directed by the physician

Alternative Brands to A-Cof

Indication

Flu, Colds, Runny nose, Dry coughs, Non-productive cough, Nasal congestion

Contra Indication

Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough.

Side Effect

Dizziness, GI disturbances.

Interaction

Dextromethorphan: Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol.

Potentially Fatal: Memantine, moclobemide.

Triprolidine + Pseudoephedrine: Increased BP with other sympathomimetic agents (e.g. decongestants, TCA, appetite suppressants). Reduced hypotensive effects of methyldopa, ?- and ?-adrenergic blockers. Increased side effects (e.g. somnolence, agitation) with atomoxetine.

Potentially Fatal: Increased risk of hypertensive crisis with furazolidine, avoid concurrent use. Increased risk of hypertensive crisis with MAOIs; avoid concurrent use or within 2 wk after stopping MAOIs. Increased risk of psychosis with bromocriptine.

Therapeutic Classes

  • Combined cough suppressants

Indicaitons

  • Cough
  • Flu
  • Cold
  • Runny nose
  • Common cold
  • Non-productive cough
  • Dry cough
  • Nasal congestion

Precaution

3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.

Mode of Action

Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine, an ?- and ?-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of ?-adrenergic receptors of the respiratory mucosa. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.