A-Migel
| Company | Acme Laboratories Ltd. | |
|---|---|---|
| Active Ingredient |  Miconazole 2% Oral | |
| Variants |
| |
Dose
For oral administration: The usual dose is 15 mg/kg/day in divided doses.
Adults : 1-2 tea-spoonfuls of gel 4 times daily.
Children aged 6 years and over : 1 tea-spoonful of gel 4 times daily.
Children aged 2-6 years : 1 tea-spoonful of gel twice daily1 month - 2 years : 1/2 tea-spoonful of gel twice daily. Localised lesions of mouth:Smear small amount on affected area with clean finger 4 times daily for 5-7 days.
Alternative Brands to A-Migel
Indication
Oropharyngeal candidiasis, Oral thrush, Denture stomatitis, Fungal infections of the mouth, Throat and gut, Angular cheilitis, Dermatomycoses, Tinea pedis, Tinea corporis, Tinea cruris, Tinea versicolor
Contra Indication
Miconazole Oral Gel is contraindicated in patients with known hypersensitivity to any of its components and in patients with liver dysfunction.
Side Effect
Nausea, vomiting, diarrhoea (with long-term treatment); rarely allergic reactions; isolated reports of hepatitis.
Interaction
May increase anticoagulant effect of warfarin. May increase or prolong the effect of the following drugs: Oral hypoglycaemics (e.g. sulfonylureas), phenytoin, HIV protease inhibitors (e.g. saquinavir), antineoplastic agents (e.g. vinca alkaloids, busulfan, docetaxel), Ca channel blockers (e.g. dihydropyridines, verapamil), immunosuppressive agents (e.g. ciclosporin, tacrolimus, sirolimus), carbamazepine, cilostazol, buspirone, disopyramide, alfentanil, sildenafil, alprazolam, brotizolam, midazolam IV, rifabutin, methylprednisolone, trimetrexate, ebastine and reboxetine.
Potentially Fatal: Increased risk of cardiac arrhythmia w/ astemizole, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, terfenadine. May increase exposure to ergot alkaloids leading to ergotism. May increase the risk of rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. simvastatin and lovastatin). May increase the effect of triazolam and oral midazolam.
Therapeutic Classes
- Mouth & Throat preparations
Indicaitons
- Candidiasis
- Oropharyngeal candidiasis/Thrush
- Mucosal candidiasis
- Candida albicans
- Denture stomatitis
- Fungal infections of the mouth Throat and gut
- Angular cheilitis
- Dermatomycoses
- Oral candidiasis/Thrush
- Intestinal or oropharyngeal candidiasis
Precaution
Caution is required particularly in infants & young children to ensure that the gel does not obstruct the throat.
Mode of Action
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.