ACE XR
| Company | Square Pharmaceuticals Ltd. | |
|---|---|---|
| Active Ingredient |  Paracetamol | |
| Variants |
| |
Dose
Tablet
Adult: 1 - 2 tablets every 4 to 6 hours up to a maximum of 4 g (8 tablets) daily
Children (6 - 12 years) : 1/2 to 1 tablet 3 to 4 times daily
Syrup
Children: 2 months: 60 mg (1/2 measuring spoonful) for post immunization pyrexia;
Under 3 months (on doctor's advice only) : 10 mg/kg (5 mg/kg if jaundiced)
3 months - 1 year : 60 - 120 mg (1/2 - 1 measuring spoonful),
1 - 5 years : 1 - 2 measuring spoonful
6 - 12 years : 2 - 4 measuring spoonful
Paediatric Drops
Children Up to 3 months: 0.5 ml (40 mg)
4 to 11 months: 1.0 ml (80 mg)
1 to 2 years: 1.5 ml (120 mg)
2 to 3 years: 2 ml (160mg)
4 to 5 years: 3 ml (240 mg)
Dose can be repeated, every 4 hours.
For Suppository: Suppository should be administered rectally.
Children: 3 months-1 year: 60-125 mg
1-5 years: 125-250 mg
5-12 years: 250-500 mg
These doses may be repeated every 4-6 hours as necessary (maximum 4 doses in 24 hours).
Adults & children over 12 years: 500 mg-1 g every 4-6 hours to a maximum of 4 g daily.
Alternative Brands to ACE XR
- Xcel
- Xcel DISPERSABLE
- Xcel ER
- Fast
- Fast Pad
- Fast XR
- Feva
- Archi
- Paracetamol
- Paracetamol Forte
- Tempil
- Alkaparol
- Act
- Act Plus
- Para
- Tempanil
- Tamol
- Promel
- Xpa
- Xpa XR
- Tempol
- Fap
- Orpa
- Bepol
- Napa
- Napa DT
- Napa Extend
- Napa IV
- Aceta
- Aceta Extend
- Neopara
- Centamol
- Nova
- Cpmol
- D Cetamol
- Depyrin
- Depol
- Cetadol
- Tydenol
- Tamen
- Tamen DT
- Tamen XR
- Enyl
- Pam
- Timidal
- ATP
- Parapyrol
- Pol
- G Paracetamol
- Tempac
- Hepa
- Longpara
- Sinapol
- Reset
- Zerin
- Atopen
- Painil
- Prefer
- Tandamol
- Pyrac
- Dola
- M-Pol
- 2 A
- FEA XR
- Fea
- Nipa
- Tamino
- Tamino ER
- Servigesic
- Renova
- Renova XR
- Fevac
- Paret
- Cetam
- Pyramol
- Analpain
- Paraxia
- Anapol
- Tylen
- Aceto
- Acetophane
- Remalgin
- Pyralgin
- Asta
- Tynol
- Paramol
- Asmol
- Silpol
- Preduet
- Silpa
- Actol
- Seridol
- Ace
- Cetal
- Fibi
- Acep
- Parafen
Indication
Mild to moderate pain and fever
Contra Indication
Hypersensitivity.
Side Effect
Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Potentially Fatal: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage.
Interaction
May reduce serum levels w/ anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins w/ prolonged use. Accelerated absorption w/ metoclopramide and domperidone. May increase serum levels w/ probenecid. May increase serum levels of chloramphenicol. May reduce absorption w/ colestyramine w/in 1 hr of admin. May cause severe hypothermia w/ phenothiazine.
Therapeutic Classes
- Non-Opioid Analgesics
Indicaitons
- Osteoarthritis / degenerative arthritis
- Musculoskeletal and joint pain
- Fever
- Headache
- Acute sore throat
- Muscle aches
- Back pain
- Acute bacterial ear infections
- Cancer pain
- Muscle spasm
- Chronic low back pain
- Musculoskeletal pain
- Joint stiffness
- Bodyache
- Pain and inflammation
- Mild to moderate pain and fever
- Pain and fever
- Kawasaki disease and dermatomyositis. sarcoidosis
- Relieve pain
Precaution
Renal or hepatic impairment; alcohol-dependent patients; G6PD deficiency.
Mode of Action
Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.