ACF
| Company | Decent Pharma Laboratories Ltd. | |
|---|---|---|
| Active Ingredient |  Aceclofenac | |
| Variants |
| |
Dose
Adult: PO Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis 100 mg twice daily.
Alternative Brands to ACF
- Celofen
- Apitac
- Fleco
- Aclovix
- Aceclofenac
- Aclo
- Penac-AC
- Apeclo
- Apeclo SR
- Acflam
- Mervan
- Mervan SR
- Ena
- Aceclofen
- Acebid
- Acegic
- A-Pak
- Acecloben
- Zolfin
- Clof
- Acelock
- Acelon
- Painex
- Acedol
- Dolonac
- Analgen
- Xtrafen
- Xtrafen SR
- Xe Fast
- Hifenac
- Nofenac
- Ecena
- Paino
- Tuffox
- Fixonac
- Pankil
- Xpain
- Acefenac
- Aros
- Ezemove
- Movon
- Ternilla
- Ceconac
- Preservin
- Reservix
- Reservix SR
- Relise
- Alona
- Xeriflam
- Labenac
- Polynac
- Aceclora
- Acenac
- Lofam
- ACN
- Nostrin
- Rheuma
- Zerodol
- Flexivan
- Flexivan ER
- Vaxtin
- Xerolin
- Servex
- Ruclon
- Freemax
- Movex
- Orcenac
- Noak
- Ceclonac
- Ac PR
- Xerifen
- Motifen
- Aclonac
- Grofenac
- Avenac
- Aclopain
- Protilez
- Ceclofen
- Repidor
- Volfenac
- Qrip
- Senac - A
- Sapclo
- Zolonac
- Orifen
- Ostoflex
- Flexi
- Flexi SR
- Xyfen
- Syclofen
- Painkil
- Acepro
- Lofens
- Acecol
Indication
Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis;
Contra Indication
Hypersensitivity to aspirin or NSAIDs; moderate to severe renal impairment; pregnancy (3rd trimester); history of peptic ulceration or GI bleed; patients with infections.
Side Effect
Diarrhoea, nausea, dyspepsia, abdominal pain, dizziness, rashes; increased LFTs.
Potentially Fatal: Severe GI bleeding; nephrotoxicity; blood dyscrasias.
Interaction
May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.
Therapeutic Classes
- Drugs used for Rheumatoid Arthritis
- Drugs for Osteoarthritis
Indicaitons
- Osteoarthritis / degenerative arthritis
- Ankylosing spondylitis
- Pain
- Spondylitis
- Pain and joint stiffness
- Bodyache
- Pain and fever
- Rheumatoid Arthritis (RA)
- Relieve pain
Precaution
Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly.
Mode of Action
Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.