AH
| Company | Drug International Ltd. | |
|---|---|---|
| Active Ingredient |  Albendazole | |
| Variants |
| |
Dose
Adult: PO Echinococcosis >60 kg: 400 mg twice daily; <60 kg: 15 mg/kg/day (max: 800 mg/day) in 2 divided doses. Duration: 28 days/cycle. Cystic echinococcosis: Up to 3 cycles w/ 14 treatment-free days in between cycles. Alveolar echinococcosis: Treatment cycles may need to be continued for mths or yrs w/ 14 treatment -free days in between cycles. Neurocysticerosis >60 kg: 400 mg twice daily; <60 kg: 15 mg/kg/day (max: 800 mg/day) in 2 divided doses. Duration: 8-30 days. Intestinal nematode infections 400 mg as a single dose. Strongyloidiasis 400 mg 1-2 times/day for 3 consecutive days, may repeat after 3 wk if needed. Giardiasis 400 mg/day for 5 days. Ascariasis; Enterobiasis; Hookworm infections 400 mg as a single dose.
Child: >2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose.
Alternative Brands to AH
- Sintel
- Ben A
- Ben-A
- Aldaben
- Aldaben DS
- Albenda DS
- Albendazole
- Chuben
- Triben
- Triben DS
- Zoben
- Abentel
- Asiben
- Verben
- Benz-24
- Alphin DS
- Azole
- Benda DS
- Albazol DS
- Nematox DS
- Q ben DS
- Colaz
- Cosben
- Alarm
- Aldes
- Aldes-DS
- Aldew
- Infesen
- E Ben
- E Ben DS
- Eben
- Alben
- Alben DS
- Parnil DS
- AL
- Al
- Aldex
- Aldex DS
- Alzed
- Al DS
- Albendol
- G Albendazole
- H Ben
- Estazol
- Albendox
- Elmin
- Adze
- Almin
- Exworm
- Mebel
- Mebel DS
- Albrex
- Durazol
- Helben DS
- Krimizole
- Krimizole DS
- Alba
- Vermin DS
- Vermikil
- Benfast
- Albizol
- Olv
- Alpro
- Xben
- NT-Par
- Chir-DS
- R-Zol
- Alentin
- Alentin DS
- Anthel
- Vermid
- Almex
- Alda
- Alda DS
- Wormex
- Aldin DS
- Albicon DS
- Albezen
- Albamax DS
Indication
Helminthiasis, Echinococcosis, Neurocysticercosis, Enterobiasis, Ascariasis, Hookworm infections, Strongyloidiasis, Giardiasis, Filariasis
Contra Indication
Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.
Side Effect
GI discomfort, headache, nausea, dizziness, allergic reactions, pruritus, raised liver enzymes, alopecia and dry mouth.
Potentially Fatal: Bone marrow depression.
Interaction
Increased serum concentrations w/ dexamethasone, praziquantel and cimetidine. Decreased serum concentrations w/ aminoquinoline (antimalarials), carbamazepine, phenobarbital, and phenytoin.
Therapeutic Classes
- Anti-helminthic
Indicaitons
- Helminthiasis
- Echinococcosis
- Neurocysticercosis
- Enterobiasis
- Ascariasis
- Hookworm infections
- Strongyloidiasis
- Giardiasis
- Filariasis
- Pulmonary eosinophilia
- Loiasis
- Toxocariasis
- Gnathostomiasis
- Ancylostomiasis
- Trichuriasis
- Trichinellosis
- Worm infections
- Trichinosis
Precaution
Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.
Mode of Action
Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecratory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.