AMX
| Company | NIPRO JMI Pharma Limited | |
|---|---|---|
| Active Ingredient |  Amoxicillin | |
| Variants |
| |
Dose
Adult: PO Susceptible infections 250-500 mg 8 hrly. Uncomplicated gonorrhoea W/ probenecid: 3 g as a single dose. Dental abscesses 3 g, repeat once 8 hr later.
Uncomplicated acute UTI 3 g, repeat once 10-12 hr later. Prophylaxis of endocarditis 2 or 3 g as a single dose, 1 hr before dental procedure.
Severe or recurrent resp tract infections 3 g twice daily.
H.pylori infection W/ either metronidazole or clarithromycin and a bismuth compound or an antisecretory drug: 500 mg 3 times/day.
Child: <10 yr: 125-250 mg every 8 hr; <40 kg: 20-40 mg/kg daily in divided doses every 8 hr. Max dose: Infant <3 mth: 30 mg/kg daily in divided doses every 12 hr.
IV/IM Susceptible infections 500 mg 8 hrly. Listerial meningitis W/ other antibiotics: 2 g 4 hrly for 10-14 days.
Child: >10 yr: 50-100 mg/kg daily in divided doses.
Renal impairment: Patients on haemodialysis should receive 250-500 mg every 24 hr and an additional dose during and after each dialysis session.
CrCl (ml/min)
10-30 250-500 mg every 12 hr.
<10 250-500 mg every 24 hr.
Alternative Brands to AMX
- Avlomox
- Avlomox DS
- Moxilin
- Moxilin DS
- J Mox
- Almoxil
- Mimox
- Sapox
- Sapox DS
- Sapox-DS
- Ambeexin
- Monamox
- Monamox DS
- Monomox
- Pemox
- Apoxy
- Apoxy DS
- Apimox
- Aristomox
- Loxyl
- Moci
- Benoxil
- Benoxil DS
- Tycil
- Tycil DS
- Amotid
- Amotid F
- Bpmox
- Cemoxin
- Brodamox
- Brodamox DS
- Amoxic
- Moxa
- Demox
- Amox
- Demoxil
- Demoxil DS
- E Mox
- Sk Mox
- Sk Mox DS
- Unimox
- Genamox
- Amoxil
- Amoxil FORTE
- Ultramox
- G Amoxicillin
- G Amoxycillin
- Dopen
- Hi Mox
- Mox PLUS
- Sinamox
- Sinamox DS
- Indomoxin
- Jamoxil
- Amoxon
- Kamoxy
- Kumumox
- Moxatid
- Amoxicon
- Hiconcil
- Hioncil
- Hectamox
- Hectamox DS
- Amoxima
- Mymoxcil
- Navamox
- Moxapen
- AMX
- Servimox
- Moxin
- Moxin PR
- Orixyl
- Amocin
- Pamoxil
- Pharmoxyl
- Fimox
- Amoxirak
- Antif
- Remamox
- Amoxi
- Amoxicap
- Bactamox
- Bactamox IM/IV
- Remoxin
- Amoxipan
- Fimoxyl
- Fimoxyl DS
- Seemaxyl
- Seemaxyl DS
- Mumox
- Mumoxs
- Simox
- Simox DS
- Simox S
- Tymox
- Amocap
- Moxacil
- Moxacil 875
- Moxacil DT
- Moxacil FORTE
- Moxico
- Moxico DS
- Amocil
- Penmox
- Amoxizen
- Amoxizen DS
- Elimox
Indication
Bacterial infections,Pharyngitis,Acute otitis media,Acute bacterial sinusitis,Endocarditis,Anthrax,Chlamydial cervicitis,Chlamydial urethritis,Lyme disease,Dental abscess,Salmonellosis,Typhoid fever,Acute Uncomplicated gonorrhea,Infections of the Lower Respiratory Tract,Skin and Skin Structure,Genitourinary Tract,Ear,Nose,Throat
Contra Indication
Hypersensitivity
Side Effect
Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis.
Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis.
Interaction
May reduce the efficacy of OC. May increase the effect of anticoagulants. Increased risk of allergic reactions w/ allopurinol. Increased and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin.
Therapeutic Classes
- Broad spectrum penicillins
Indicaitons
- Bronchiectasis
- Acute sore throat
- Bacterial infections
- Pharyngitis
- Acute otitis media
- Acute bacterial sinusitis
- Endocarditis
- Anthrax
- Chlamydial cervicitis
- Chlamydial urethritis
- Lyme disease
- Dental abscess
- Salmonellosis
- Typhoid fever
- Infections of the Lower Respiratory Tract
- Paratyphoid fever
- Septicaemia
- Bacterial endocarditis
- Streptococcal pharyngitis/tonsillitis
- Chlamydial infections
- Lower Respiratory Tract Infections
- Gonorrhoea
- Uncomplicated pneumococcal pneumonia
- Streptococcal pharyngitis
- Sore throat
- Cellulitis
- Aspiration pneumonia
- Upper and lower respiratory tract infections
- Pharyngitis and Tonsillitis
- Acute Exacerbations of Chronic bronchitis
- Enteric fever
- Genitourinary tract infections
- Whipple's disease
- Periodontitis
- Middle ear infections (otitis media)
- Boils
- Throat infections
- Uncomplicated gonorrhoea
- Abscesses
- Acute necrotising ulcerative gingivitis
- Diverticulitis
- Lower urinary tract infections
- Nongonococcal cervicitis
- Bronchopneumonia
- Haemophilus influenzae type b infection
- Bacteraemic pneumonia
- Pneumococcal pneumonia
Precaution
Renal and hepatic disease; pregnancy, lactation; infectious mononucleosis.
Mode of Action
Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.